Entry Date:
October 29, 2013

Nanoparticles for Drug Delivery

Principal Investigator Rohit Karnik

Co-investigators Omid Farokhzad , Robert Langer

Biodegradable lipid and polymeric nanopoarticles with the ability to target diseased tissue and release drugs in a controlled manner are highly promising as carriers for drug therapy. We are using microfluidic devices for synthesis of polymeric nanoparticles with tunable properties and homogeneous distributions. Our aim is to control their properties such as size, charge, homogeneity, and drug loading by rapid mixing of precursors during nanoprecipitation. These devices are being used for understanding the role of nanoparticle properties on their in vitro and in vivo behavior to develop nanoparticles and to optimize them for different applications.