Principal Investigator Steven Tannenbaum
Co-investigator John Wishnok
Project Website http://web.mit.edu/toxms/www/ujjal.htm
Primary focus is on a drug metabolism, pharmacokinetics, and metabolomics-based small molecule biomarker discovery study to develop 3D microphysiological systems containing ten living human cell types, including liver, gut, lung, and reproductive cells connected via a microfluidic interacting circuit system. This research program, a collaboration among MIT, the Charles Stark Draper Laboratories, and CN Bio Innovations, Ltd., is funded by the US Defense Advanced Research Projects Agency (DARPA). My work emphasizes the development of liquid chromatography tandem mass spectrometry assays, and integration of measurements, kinetics and metabolism data to support collaborators who are integrating individual systems along with new modules in a physiological meaningful way, emphasizing how the interplay between epithelial, stromal and immune cells governs toxicological response to drugs and potential drug candidates.