Principal Investigator Omid Farokhzad
We emphasize a fundamental understanding of how nanomaterials interact with biological systems, such as cancer cells and cardivasculature. The performance of nanoparticle drugs often depends on the sensitive interplay between the multiple functionalities of the nanoparticle and its response to the biological environment, which, in turn, can impact the transport, distribution, and drug release of the nanoparticles. The knowledge of how nanoparticle properties change with correspondence to the biological environment can aid in the design of nanoparticle drugs. Using this knowledge, we can then control the physical chemical properties, composition, and formulation process of the nanoparticles themselves.