Using biocompatible and biodegradable polymers for targeted drug delivery not only improve drug safety, but also significantly shorten the timeline of drug development. We are particularly interested in using PLA- and PLGA-based drug delivery systems and strive to improve their therapeutic efficacy. We also develop novel chemistry to conjugate and encapsulate a variety of small molecule drugs. Finally, we explore methods that will further functionalize polymer backbones so that the polymer is suitable to carry both hydrophobic and hydrophilic therapeutic agents.