Principal Investigator Omid Farokhzad
Molecules that target biomarkers of a specific disease play an important role in nanoparticle drug delivery. These molecules, used in nanoparticle delivery systems, increase nanoparticle in vivo efficacy and significantly affect the biodistribution and pharmacokinetics of the uptake of such particles. We seek to develop advanced technologies, such as bacterial phage display and SELEX, in order to discover targeting moieties of high specificity and affinity, including small molecules, peptides, antibodies, and aptamers. Using these molecules, we can develop novel conjugation techniques and engineering processes to formulate particles that target a variety of diseases.