Principal Investigator Iain Cheeseman
The kinetochore is a key site of regulation by the cell as it must respond to cell cycle state, and also monitor and correct any errors in chromosome-microtubule attachments. At least six mitotic kinases appear to function at regulate this structure. However, despite extensive work on these kinases, the key downstream targets for these kinases at kinetochores, and the consequences of specific phosphorylation, remain largely unknown. We have identified multiple phosphorylation sites within the human kinetochore and working to understand the contributions of these sites to chromosome segregation.