Principal Investigator Leonid Mirny
We examined the structure of the first networks of protein-protein interactions, demonstrated their modular organization, and developed algorithms and statistical tools to detect such modules. We studied the structure and evolution of the metabolic network and demonstrated that the modules that evolve as a unit differ from traditional definitions of distinct metabolic pathways. We also developed a novel algorithm to study networks of chemical reactions and demonstrated that the topology of the metabolic network is sufficient to predict its response to perturbations.