Principal Investigator Gerald Fink
The cell surface molecules of fungi vary by both genetic and epigenetic mechanisms that confuses the immune system. The beta-glucan and the mannoproteins on the surface of fungi are the signature molecules recognized by the phagocytic cells of the immune system in their attempt to destroy pathogens. But, fungi have genetic, epigenetic and regulatory mechanisms that change the ensemble of surface molecules to avoid or alter recognition. The surface mannoproteins (adhesins) of Saccharomyces cerevisiae, Candida albicans and Candida glabrata form a superfamily united by a common structure consisting of three domains (A, B, C). The amino terminal domain (A) provides much of the affinity for surfaces. This domain is followed by a segment of variable length (B) that is extremely rich in serines and threonines and contains many tandem repeats. The carboxyterminal region (C), links the mannoprotein to the beta-glucan.