Principal Investigator George Daley
Project Website http://daley.med.harvard.edu/Daley_Lab_Hematopoiesis.htm
Hematopoiesis is the term applied to the myriad processes resulting in blood cell production. The description of hematopoietic stem cell activity stands as a tremendous scientific milestone of the last century and was a culmination of many studies. Moreover, the detailed analysis of hematopoiesis also directly facilitated the development of a profoundly beneficial medical intervention, namely blood stem cell transplantation; a stunning example of the key role that basic research plays in improving human health.
The laboratory has a keen interest in understanding the process of hematopoiesis at all levels including the specification of blood tissue in the developing embryo and mechanisms contributing to efficient transplantation of blood-forming activity. Work in hematopoiesis bridges our interests in pluripotent cell biology and cancer therapeutics with projects in the derivation and engraftment of lympho/myeloid repopulating activity from a pluripotent cell starting point as well as the study of blood formation in disease-specific contexts.