Principal Investigator Timothy Swager
We are engaged in active collaborations directed at optical and NMR imaging. In the case of optical systems we have a collaboration with the Alzheimer's Disease Research Unit at the Massachusetts General Hospital (Professors Brian Bacskai and Bradley Hyman). We are focusing on the development of far red dyes that can be imaged in vivo and selectively bind to and fluoresce when bound to amyloids in the brain ( "In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers"Angew. Chem. Int. Ed. 2005, 44, 5452-5456). In NMR imaging we are collaborating with Professor Robert Griffin on the synthesis of diradicals that can be used in Dynamic Nuclear Polarization to create population inversions that give locally enhance 13C NMR emissions.