Project Website http://web.mit.edu/~narendra/www/index.html
Interests lie in two broad areas:
(1) probing and understanding the dynamics of gene regulation and how those dynamics can lead to large variability in gene expression amongst even a genetically homogeneous populations (2) developing methods to rapidly introduce variability in protein expression and sequence for the directed evolution of multigenic traits
The Group takes an interdisciplinary and often quantitative approach to these problems that involves combining theory, computation and experiment. Focus is in vivo and we exploit budding yeast in much of our work due to its facile genetics and molecular biology.