Principal Investigator Eric Lander
One of the great frontiers of genomics is identifying and understanding the regulatory elements that control the expression of genes. Deciphering this regulatory code involves both experimental and computational approaches. Current projects include: techniques for identifying conserved regulatory elements in promoters, UTRs and other genomic regions; large-scale discovery of the binding sites of regulatory proteins through chromatin immunoprecipitation; analysis of microRNAs and their target sites; and mass-spectrometric identification of proteins binding to particular DNA elements.