Principal Investigator David Housman
The goal of this project is to utilize high throughput genomic methodologies to identify genes contributing to various aspect of tumorigenesis in the InkD2/3 -/- tyr-rasV12G mouse melanoma model system. The goal is to identify genes which contribute to the development of melanoma through studies of LOH in tumors and the mapping of modifier genes which accelerate or retard tumorigenesis in this model.