In June of this year, MIT will complete the construction of the MIT.nano, an 18,000 sq.m. facility in the middle of the campus for MIT’s nanotechnology-related activities. This facility is, in effect, an acknowledgement of the nanotech’s importance today. Within MIT.nano, SENSE.nano is its first Center of Excellence. The impetus for SENSE.nano is the recognition that novel sensors and sensing systems are bound to provide previously unimaginable insight into the condition of individuals, as well as the built and natural world, to positively impact people, machines, and environment. Advances in nano-sciences and nano-technologies, pursued by many researchers at MIT, now offer unprecedented opportunities to realize designs for, and at-scale manufacturing of, unique sensors and sensing systems, while leveraging data-science and IoT infrastructure.