With the proliferation of commercial wearable devices, we are now able to obtain unprecedented insight into the ever-changing physical state of our bodies. These devices allow real-time monitoring of biosignals that can generate actionable information to enable optimized interventions to avoid injury and enhance performance. Combat and medical planners across all military services are keenly interested in harnessing wearable sensor advances to diagnose, predict, and improve warfighter health and performance. However, moving from civilian promise to military reality is complex, with unique requirements of hardware design, real-time networking, data management, cybersecurity, predictive model building, and decision science. Emerging technologies for military on-the-move monitoring will be highlighted, along with a discussion of an integrated open systems architecture approach for functional evolution.