Prof. Morgan Hwa-Tze Sheng

Professor of Neuroscience
Core Institute Member, Broad Institute
Co-Director, Stanley Center for Psychiatric Research, Broad Institute
Affiliate Member, Picower Institute for Learning and Memory
Affiliate Member, McGovern Institute for Brain Research

Primary DLC

Department of Brain and Cognitive Sciences

MIT Room: NE30-75A-9023

Assistant

Sonya Best
sbest@broadinstitute.org

Areas of Interest and Expertise

Synaptic Plasticity
Neurodegeneration
Therapeutics
Psychiatric Disorders

Research Summary

Morgan Sheng focuses on the structure, function, and turnover of synapses, the junctions that allow communication between brain cells. His discoveries have improved our understanding of the molecular basis of cognitive function and diseases of the nervous system, such as autism, Alzheimer’s disease, and dementia. Being both a physician and a scientist, he incorporates genetic as well as biological insights to aid the study and treatment of mental illnesses and neurodegenerative diseases. He rejoins the Department of Brain and Cognitive Sciences (BCS), returning as a professor of neuroscience, a position he also held from 2001 to 2008. At that time, he was a member of the Picower Institute for Learning and Memory, a joint appointee in the Department of Biology, and an investigator of the Howard Hughes Medical Institute. Sheng earned his PhD from Harvard University in 1990, completed a postdoc at the University of California at San Francisco in 1994, and finished his medical training with a residency in London in 1986. From 1994 to 2001, he researched molecular and cellular neuroscience at Massachusetts General Hospital and Harvard Medical School. From 2008 to 2019 he was vice president of neuroscience at Genentech, a leading biotech company. In addition to his faculty appointment in BCS, Sheng is core institute member and co-director of the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, as well as an affiliate member of the McGovern Institute and the Picower Institute.

Recent Work