Entry Date:
January 25, 2016

The Brain's Balancing Act

Principal Investigator Yingxi Lin

Like a conventional electrical circuit, the brain uses both positive and negative components to amplify desirable signals while maintaining the overall stability of the system. Yingxi Lin wants to understand how this balance between excitation and inhibition is established during development and then maintained throughout life. The underlying molecular mechanisms are not well understood, but inhibitory neurons and their synaptic connections, which are readily modified by activity, are likely to play a critical role.