Entry Date:
April 27, 2010

Developing Inhibitions

Principal Investigator Yingxi Lin

As a postdoctoral researcher, Lin identified a transcription factor known as Npas4 that appears to be a master regulator of inhibitory synapse development. In her laboratory at the McGovern Institute, she will use a combination of molecular, genetic, and electrophysiological approaches to understand how Npas4 controls this process, and to identify additional molecules that are important for inhibitory synapses. She also plans to study the development of inhibitory neurons, in particular how the function of these neurons is shaped by activity and experience during early life.