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39 mins
ILP Video

Revolutionizing Medical Device Design

Charles Sodini
Clarence J LeBel Professor of Electrical Engineering
MIT Department of Electrical Engineering and Computer Science
The vision of the MIT Medical Electronic Device Realization Center (MEDRC) is to revolutionize medical diagnostics and treatments by bringing health care directly to the individual and to create enabling technology for the future information-driven healthcare system. This vision will in turn transform the medical electronic device industry. Specific areas that show promise are wearable or minimally invasive monitoring devices, medical imaging, portable laboratory instrumentation, and the data communication from these devices and instruments to healthcare providers and caregivers.

Rapid innovation in miniaturization, mobility, and connectivity will revolutionize medical diagnostics and treatments, bringing health care directly to the individual. Continuous monitoring of physiological markers will place capability for the early detection and prevention of disease in the hands of the consumer, shifting to a paradigm of maintaining wellness rather than treating sickness. Just as the personal computer revolution has brought computation to the individual, this revolution in personal medicine will bring the hospital lab and the physician to the home, to emerging countries, and to emergency situations. These system solutions containing state-of-the-art sensors, electronics, and computation will radically change our approach to health care. This new generation of medical systems holds the promise of delivering better quality health care while reducing medical costs.

In this talk I will introduce the research directions of the MEDRC and discuss the circuit and system design issues and clinical measurements from selected MEDRC projects highlighting wearable monitoring.
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32 mins
ILP Video

Model-based Physiologic Monitoring: Leveraging Real-time Data and Models for Improved Clinical Inference

Thomas Heldt
Assistant Professor of Electrical Engineering and Computer Science
Hermann von Helmholtz Career Development Assistant Professor
Principal Investigator, Research Laboratory of Electronics (RLE)
Large volumes of multivariate physiologic data can now be routinely acquired from patients using wearable and non-wearable sensor systems. To leverage such volumes of data for improved clinical care, a key question needs to be addressed, namely how to turn the raw data streams into clinically actionable information. One approach is to mine the data from a large population of subjects to identify features and patterns that might be indicative of certain conditions. A complimentary approach focuses on our knowledge of the relevant physiology to build mathematical models of the functional relationships between different signals. These models can then be used to summarize the data streams and to estimate parameters that are of direct clinical interest.

In this talk, I will describe our work in model-based physiologic monitoring and highlight recent progress in estimating important cardiac and neurovascular properties from readily available bedside monitoring data streams.
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24 mins
ILP Video

Health-Tech Innovation

Anshuman Das
Postdoctoral Associate
Head, Camera Culture Group
MIT Media Lab
The Camera Culture Group at the MIT Media Lab aims to create a new class of imaging platforms, making the invisible visible by using a new generation of cameras to see outside and inside our bodies. The group accomplishes this goal in 2 ways: by building affordable health diagnostics and by organizing health-tech partnerships to bring together MIT’s excellence in technology, innovation, engineering and entrepreneurship with global community partners skilled in providing quality health care.

One diagnostic, EyeNetra, is a mobile phone attachment that allows users to test their own eyesight. The device reveals corrective measures thus bringing vision to billions of people who would not have had access otherwise. Another project, eyeMITRA, is a mobile retinal imaging solution that brings retinal exams to the realm of routine care, by lowering the cost of the imaging device to a 10th of its current cost and integrating the device with image analysis software and predictive analytics. This provides early detection of Diabetic Retinopathy that can change the arc of growth of the world’s largest cause of blindness.

The health-tech partnerships aim to create community-responsive, patient-centric, innovative technology solutions to address pressing health challenges, locally engage and develop the next generation of entrepreneurs, engineers, and researchers within partner communities, foster a strategically structured global ecosystem for purposeful innovation, significantly accelerate the development and deployment of targeted, cost-effective, globally scalable health technologies for first-mover advantage, and to deploy new health technologies that stand to disrupt and greatly improve the way health care is practiced in both partner communities and around the world.

At the foundational core of these HealthTech collaborative partnerships will be MIT-facilitated weeklong “boot camps” held on-location in global partner communities. In addition to sharing information on the co-development model, Ramesh Raskar will also share success stories from several of his group members and from other “bootcamp” participants.
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37 mins
ILP Video

GaN, Graphene and Other Extreme Materials for Future Electronics

Tomás Palacios
Emmanuel Landsman CD Associate Professor of Electrical Engineering
MIT Department of Electrical Engineering and Computer Science
Electronics is at a crossroads. Most of the technologies that have enabled the electronics revolution of the last 40 years are no longer useful. If we want electronics to continue improving its performance and, along the way, continue driving a countless number of other industries, we need novel materials and device concepts. In this talk, we will discuss the new opportunities enabled by two extraordinary material families: GaN and layered semiconductors like graphene and MoS2.

First, we will focus on GaN, a wide bandgap semiconductor with ideal properties to address the energy challenge our society is currently facing. Through solid state lighting and power electronics, GaN semiconductor devices could save more than 20% of the world´s energy consumption. In this talk we will describe some of the devices that will make this happen.

At the opposite end of the bandgap spectrum, graphene, a two-dimensional structure of carbon atoms with sp2 bonding, has demonstrated the highest electron and hole mobility at room temperature in any semiconductor material. We will describe how this one-atom-thick material is quickly becoming the building block for a new generation of ubiquitous electronics.
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43 mins
ILP Video

Bulk Nanostructured Materials for Advanced Structural Applications - Mechanical and Multifunctional Properties

Brian Wardle
Associate Professor of Aeronautics and Astronautics
Director, Nano-Engineered Composite Aerospace Structures (NECST) Consortium
MIT Department of Aeronautics and Astronautics
Bulk nanostructured materials offer tremendous opportunity for re-inventing materials, but also pose many challenges both in terms of characterization, design, processing, and scaling. This presentation will focus on recent work developing nanoengineered hierarchical advanced composites with a focus on enhancing mechanical properties. Such hybrid advanced composites employ aligned nanowires (in our work, carbon nanotubes, CNTs) in several architectures to enhance laminate-level bulk properties of existing aerospace-grade advanced composites. Intrinsic and scale-dependent characteristics of the CNTs are used to engineer bulk property improvements including critical mechanical design parameters for composite laminates such as open-hole compression (OHC) and tension bearing strengths. Building multifunctionality concurrent with these mechanical property improvements includes thermal and electrical conductivity tailoring for damage detection and ice protection, among others. Fundamental studies on polymer-CNT interactions led to the development of a combined top-down and bottom-up fabrication methodology that addresses several of the key issues (agglomeration, viscosity, CNT wetting, scale, alignment) that have frustrated the use of nanomaterials in bulk materials, particularly advanced composites. New research directions, particularly new applications in related disciplines such energy storage and transport, will be highlighted.
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