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38 mins
ILP Video

Nanoelectronics for Chemical- and Bio-sensing

Timothy Swager
John D. MacArthur Professor of Chemistry
MIT Department of Chemistry
This lecture will describe the conceptual design and optimization of chemical/biological sensors based upon conjugated polymers (CPs) and carbon nanotubes. The ability of these materials to produce amplification in a fluorescence- or resistance-based chemosensor stems from the transport optical excitations or electrical charge, respectively, over large distances. These transport properties provide the increased sensitivity and versatility of CPs over small-molecule chemosensors. The detection of enzymes and DNA will be highlighted.
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36 mins
ILP Video

Concentration-Enhanced Molecular Binding and Activity Assays using Microfluidic Biomolecule Concentrator

Jongyoon Han
Associate Professor
MIT Department of Biological Engineering
MIT Department of Electrical Engineering and Computer Science
In many biosensing application, low abundance of target molecules significantly limit both sensitivity and specificity of the detection. In this talk, I will describe several microfluidic devices and strategies that can concentrate target molecules and enhance detection sensitivities. Concentration-enhanced biosensing can be applied to many different sensing modalities, including various binding and enzymatic assay chemistry. Microfluidic concentration system can also be implemented in a continuous-flow format, which enables seamless integration with downstream sensors.
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31 mins
ILP Video

Rapid Strain-Level Discrimination of Pathogenic Bacteria Using Insulator-Based Dielectrophoresis

Cullen R. Buie
Assistant Professor
Mitsui Career Development Chair
MIT Department of Mechanical Engineering
We present three-dimensional insulator-based dielectrophoresis (3DiDEP) as a high sensitivity approach for rapid strain-level discrimination bacteria. In this work, 3DiDEP was performed on Pseudomonas aeruginosa PA14 along with six isogenic mutants as well as Streptococcus mitis SF100 and PS344. Strain-level discrimination was achieved between these clinically important pathogens with applied electric fields below 10 V/mm. This low voltage, high sensitivity technique has potential applications in clinical diagnostics as well as microbial physiology research.
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25 mins
ILP Video

Enhancing Materials Performance in Extreme Environments through Design of Interfaces

Michael J. Demkowicz
Assistant Professor of Materials Science and Engineering
MIT Department of Materials Science and Engineering
Professor Demkowicz will present two examples that illustrate how controlling the structure of interfaces may be used to enhance materials performance in extreme environments. The first concerns materials in future fusion reactors, which may fail due to copious He implantation. Demkowicz will describe a way of mitigating He-induced damage by trapping He at heterophase interfaces. In the second, he will discuss how grain boundary engineering may reduce susceptibility to Hydrogen embrittlement in materials used in deep oil wells.

This talk is based on work supported by the Center for Materials at Irradiation and Mechanical Extremes, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number 2008LANL1026, the LANL LDRD program, and by the MIT-BP Materials and Corrosion Research Center.
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23 mins
ILP Video

Sustainable Metals Processing

Antoine Allanore
Thomas B King Assistant Professor of Metallurgy
MIT Department of Materials Science and Engineering
Most major mining and metallurgical processes are more than 100 years old, developed at a time of limited awareness of their environmental impact and the issue of resources limitations. These two issues are covered nowadays by the term "sustainability," which also encompasses a cost metric when applied to primary materials. Unfortunately, most easy problems limiting the operational as well as environmental costs of metals extraction and manufacturing have been solved, and innovative approaches are needed to cope with both globalization and earth intrinsic limitations. This presentation will report results directed towards the development of new techniques for metal extraction and manufacturing.
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