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Formulation and Stabilization of Biotherapeutics

June 11-13, 2018

Biotherapeutics, particularly antibodies, are currently the fastest growing pharmaceuticals. Ideally, they are formulated in aqueous solutions, often a great challenge due to physical and chemical stability issues. This course addresses those challenges across a range of topics from aggregation to oxidation, deamidation, and hydrolysis. It covers these topics from the basic to the advanced level with an emphasis on modeling. In addition, cutting-edge technologies are described and analyzed. The course as a whole focuses on giving you additional tools and knowledge to help streamline solutions to formulation and stability issues for biologics.

Who Should Attend

This course is targeted for scientists and engineers in biopharmaceutical development. It would also be of interest to those in biomanufacturing, in which stability issues perpetually arise. The course will be of particular benefit to those who wish to enhance their skill in efficiently and effectively addressing stability issues and formulation. Those who should attend include:

  • Formulation scientists from beginning to advanced
  • Scientists and engineers who are interested in or need to understand stability issues
  • Bioprocessing scientists and engineers
  • Scientists and engineers interested in physical and chemical processes that occur with biomolecules
  • Managers responsible for pharmaceutical development, manufacturing, and regulatory affairs

Multiscale Materials Design

June 11-15, 2018

As the demand for high-performance materials with superior properties, flexibility, and resilience grows, a new design paradigm from the molecular scale upwards has revolutionized our ability to create novel materials. This course covers the science, technology, and state-of-the-art in atomistic, molecular, and multiscale modeling, synthesis and characterization. Through lectures and hands-on labs, participants will learn how superior material properties in nature and biology can be mimicked in bioinspired materials for applications in new technology. Bridging multiple hierarchies of length- and time-scales, this course trains participants in applications to polymers, metals and ceramics as well as composites. The course also covers sustainable infrastructure materials such as concrete and asphalt.

This course will focus on practical problem-solving computational tools paired with a detailed discussion of experimental techniques to probe the ultimate structure of materials, emphasizing tools to predict key mechanical properties. Case studies of molecular mechanics, bio-inspired composites, and dynamic fracture of composites and polymers will be presented and carried out by participants in computational labs. Simulation codes, algorithms, and details of the implementations of different simulation technologies, including validation, will be presented, including practical issues such as supercomputing (hardware and software), parallelization, graphics processing computing (GPU), and others. Specific focus is on structural polymers and composites, including innovative material platforms such as carbon nanotubes, graphene, and protein materials for bio-inspired materials. Participants will learn state-of-the-art techniques, such as molecular dynamics and coarse-graining, used to cover a range of length- and time-scales.

Who Should Attend
This course will be of interest to scientists, engineers, managers, and policy makers working in the area of materials design, development, manufacturing, and testing. The program is of particular interest to industries where highly functional materials tailored for specific purposes are needed. The focus on mechanical properties includes domains such as biomaterials and implants, adhesives, construction materials, and structural materials for the aero-astro and automotive industries.

Nuclear Plant Safety

June 11-15, 2018

The reactor safety course (one of MIT Professional Education’s longest running summer programs) addresses from a practical point of view the safety and regulatory issues of operating and planned reactors in the US and other countries. Emphasis will be on new developments such as:

  • New reactor safety and licensing
  • International perspectives on safety
  • Risk-informed operations
  • Causes of plant outages
  • High performance fuel
  • Spent fuel storage management
  • Emergency planning - course sessions that focus on learning from the Fukushima experience.

A review of recent developments focusing on safety issues in the near-term deployment of new plants, the Generation-IV nuclear system program, and the advanced fuel cycle initiative will be among the topics of discussion. There will be a panel discussion at the end of each day comprised of that day’s lecturers to answer questions.

The Nuclear Plant Safety course is intended for degree holding engineers and scientists who have some knowledge of nuclear facility technology and who are or will be participating directly in the design, construction, operation, or regulatory safety review of large nuclear installations such as power reactors. It will be of particular interest to technically trained representatives of the electrical power utility industry, Department of Energy facilities, reactor or reactor component fabricators, safety evaluators, and other technically trained personnel interested in obtaining an overall view of reactor safety.

Quantitative Cardiorespiratory Physiology and Clinical Applications for Engineers

June 11-15, 2018

This course presents the functional anatomy, physiology, and pathophysiology of the cardiovascular and respiratory systems from an engineering perspective. The goal of the course is to enable engineers and managers from industry to understand the normal cardiorespiratory physiology at the systems level, to predict system behavior under normal operation and pathological stresses, and to understand what commonly monitored clinical signals reveal about the state of the system. Strong emphasis will be placed on describing the cardiovascular system quantitatively, drawing on physical principles and deriving models of cardiovascular and respiratory function that illuminate the organ systems’ operation. The course is structured into these major blocks:

  • Functional anatomy of the cardiovascular systems
  • Function of the heart and peripheral circulation
  • Function of the intact cardiovascular system
  • Control of the cardiovascular system
  • Physical basis of electrocardiography
  • Clinical electrocardiography
  • Functional anatomy of the respiratory system
  • Respiratory mechanics
  • Respiratory gas exchange

The course will be lecture-based, with breakout sessions in small groups to work on hands-on problems that consolidate the concepts presented during lectures. Presentations by clinicians will give insights into how technology is used in current clinical practice.

Radical Innovation

June 11-13, 2018

Less than 10 years ago, traditional players such as Nokia, Ericsson, Samsung, and Motorola dominated the mobile phone industry. Three years ago, the hottest phones were by Apple. Today, Samsung is considered an innovative company, Google has acquired the mobile phone division of Motorola, and Microsoft has acquired the mobile phone division of Nokia. Three elements of modern technology are making new ideas appear at such an extraordinary pace: the sheer rate of technical progress, the abundance of tools that are placing advanced technologies within the reach of new entrants, and the extraordinary opportunities created by convergence. Not all innovation needs to progress at this rate; however, there are lessons to be learned from these events and every company should be prepared to leverage opportunities from within or to ward off threats from the outside. The objective of this class is to cover some of the salient features of innovation in the modern world and to lay out the philosophy, tools, procedures, and incentives that an organization can adopt to drive innovation.

The course will cover a range of topics in innovation, and will begin with an understanding of what makes a successful innovative product and business: people, opportunity, context, and technology. The course will examine case studies in what we call radical innovation and will identify steps that companies can take towards encouraging innovations from within, ranging from brainstorming sessions to invention awards. Participants will also examine successful incubator strategies and critical success factors and some of the IP issues around invention. Next, the course will explore the role of venture funds inside and outside companies, and discuss spinouts, spin-ins, licensing, and acquisitions. Finally, participants in the course will consider the role of communities, standards bodies, and open-source models in innovation. There will also be breakout sessions in which smaller groups will engage in innovation exercises.

Who Should Attend

The course is taught from a technology viewpoint and is targeted at technical leaders, executives in charge of product or company strategy, and product managers. Typical titles will include: CTO, Head of Strategy, CIO, Head of R&D, Product Manager, Director of Lab, Group Leader, and so on.

Cambridge, MA

Fundamentals of Finance for the Technical Executive

June 12-13, 2018

This program is designed to provide senior technical managers with the financial concepts, strategies, and tools needed to deal more effectively with corporate financial management. Course curriculum focuses on basic financial principles for project evaluation, funding, and resource allocation, helping leaders to work more effectively with financial decision makers and apply the principles of finance to short-term and long-range goals.

Today's technical executive must be able to use finance to persuade corporate financial officers to fund projects as well as use financial tools to address senior management's concerns about risk. Focused on basic principles of accounting and financial decision making for managers, this program will help transform a technical manager?s ability to manage and advocate for both day-to-day and long-term activities. 

This interactive, hands-on program will enable participants to:

  • Understand how funding decisions are made and how they can influence those decisions by applying financial principles to project evaluation and resource allocation
  • Learn how to assess projects for their potential economic value
  • Conduct discounted cash flow (DCF) valuations

This program is designed for executives who manage project teams and departments, and technical professionals involved with R&D, product and software design, engineering, and other scientific and technical work. No advanced quantitative skills are required, but participants should bring calculators.

Past participants have included key members of technical management, such as:

  • CIOs
  • Chief technologists
  • Head scientists
  • R&D and product development directors
  • Engineering and manufacturing vice presidents
  • Corporate strategists
  • Project managers
  • Systems information managers

MIT Campus, Cambridge, Massachusetts

Achieving Operational Excellence Through People: Delivering Superior Value to Customers, Employees, and Shareholders

June 12-13, 2018

What makes a service business successful? The rule of thumb for many companies in industries like retail, hospitality, and even health care has been to drive down wages and operation costs, creating a vicious cycle of disinvestment in search of higher profits. What if the focus shifted from lower labor costs to smarter investments: creating products and services that people want to buy, jobs that people want to keep, and driving high performance? What if businesses shifted from the norm of mediocrity in customer service, productivity, jobs and wages to a new standard of excellence?

The Good Jobs Strategy: Delivering Superior Value to Customers, Shareholders, and Employees is designed to help leaders of service businesses create an organization that delivers superior value to customers, shareholders, and employees all at the same time. Through a combination of interactive case studies, lectures, and videos, participants will learn about the key elements of the good jobs strategy and how to implement that strategy in their organization. As part of this program, participants (and a sample of their frontline employees and managers) will complete a good jobs strategy assessment survey in advance of the course. The course content, combined with the data from the surveys, will help participants identify key areas for improvement and provide instruction on next steps for their organizations.

The course will leverage a systems perspective to frame discussions around key elements of the Good Jobs Strategy, including:

  • Making operational choices that increase productivity and contribution of workforce
  • Investing in workers to create a capable and motivated workforce
  • Creating a high return on employee investment
  • A value system that emphasizes customers, employees, and continuous improvement

Recent case studies from retail and health care industries will be used to explore successful improvement strategies that directly involve frontline employees.

Participants of this program will learn:

  • The cost of mediocrity and key drivers of mediocrity in organizations
  • How customer focus, employee management, work design, and improvement systems work together to create excellence for all stakeholders
  • The importance of a systems perspective that includes leadership, strategy, operations, and human resources for implementing the Good Jobs Strategy
  • Key elements of a good job for frontline employees
  • How to design an operating system that thrives financially while offering good jobs
  • How to create a high-performance environment for frontline employees

Cambridge, MA

Building Game-Changing Organizations: Aligning Purpose, Performance, and People

June 14-15, 2018

Game-changing organizations rewrite traditional playbooks. They stand out. They often create disproportionate value relative to their size and resources. They have big dreams but know how to get things done. These organizations have a palpable "buzz" to them. They have a breakaway business model, but they also have a breakaway spirit and organizational culture.

Leaders of these game-changing organizations understand the power and importance of telling their companies' compelling stories. They are hard-edged business leaders but they also embrace what others might consider to be the "soft side" of leading: purpose, vision and climate. They know how to integrate the hard and soft sides of leadership into a powerful formula that makes them game-changers. These leaders, and their organizations are: purpose-driven; performance-oriented; and principles-led. The weaving together of these three capabilities simultaneously is what helps them get and stay out in front.

Participants in this new program will learn what it takes to build game-changing organizations that make their teams and areas of responsibility world-class talent factories. They will also discuss the importance of building an authentic and energizing culture, and learn from the successes and challenges of various companies that have been on similar journeys of transformation.

Participants in this program will:

  • Understand what it takes to build game-changing organizations
  • Be provided with the resources and tools to articulate their company's powerful story--what we call their "collective ambition"
  • Examine how to integrate the "soft" side of leading (purpose, vision, culture) with the hard side (strategy, operational priorities, brand) into a powerful formula
  • Understand the importance of building an authentic and energizing culture
  • Understand what it takes to make their companies world-class talent factories