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Downstream Processing

July 25-29, 2016

Continuing discoveries in molecular biology, genetics, and process science provide the foundation for new and improved processes and products in today's biochemical process industry. The production of therapeutic proteins, which is made possible by discoveries in biotechnology, will generate sales exceeding $150 billion in 2014. In addition, biotechnology has led to marked improvement and expansion in the traditional biochemical process industry for production of enzymes, diagnostics, chemicals, pharmaceuticals, and foods. Continued introduction of new technology necessitates innovation in process development scale-up and design. As a consequence, there is the need to design new, as well as to improve existing, processes. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification.

Who Should Attend

The course covers fundamental principles of downstream processing with practical examples and case studies to illustrate the problems and solutions faced by the practitioner. It is intended to provide both insight into and an overview of downstream processing for individuals actively engaged in process research and development, as well as those who manage and innovate in the biochemical process industry. Increasingly, scientists and engineers engaged in fermentation and cell culture development attend the course to better understand the context of the whole process. Attendees include:

  • Engineers and scientists interested in design, economics, validation optimization and scale-up of biochemical product recovery;
  • Protein biochemists and chemists involved in design of recovery processes;
  • Managers responsible for biochemical process development;
  • Entrepreneurs, attorneys, and business leaders wanting an overview and insight into biochemical manufacturing.

Additive Manufacturing: From 3D Printing to the Factory Floor

July 25-29, 2016

This course will build a comprehensive understanding of additive manufacturing (AM) processes and their implications for product development and manufacturing operations. Lectures will analyze AM fundamentals, materials, and process capabilities. This content will then be related to applications spanning industries including aerospace, medical devices, electronics, architecture, and consumer products. Lab sessions will provide hands-on experience with desktop 3D printers. Participants will design, fabricate, and measure components, and will identify future opportunities via case studies.

Additive manufacturing (AM) processes were first demonstrated more than twenty five years ago; however, only recently has broad industrial and consumer interest ignited, with potential implications ranging from ubiquitous personal fabrication to disruption of traditional supply chains. The goal of this course is to present a comprehensive overview of AM, spanning from fundamentals to applications and technology trends. Participants will learn the fundamentals of AM of polymers, metals, composites, and biomaterials, and will realize how process capabilities (rate, cost, quality) are determined by the material characteristics, process parameters, and machine designs. Application areas including aerospace components, electronics, medical devices, and consumer products will be discussed via detailed examples and case studies. Particular emphasis will be placed on emerging metal- and powder-based AM technologies, and related design principles and process standards. Lab sessions will provide hands-on experience with a variety of state-of-the-art desktop 3D printers and scanners. Participants will design, fabricate, and measure test parts, and will perform experiments to explore process limits. The course will conclude with a perspective on needs for future advancement of AM and major opportunities spanning many related business and technical domains.

Beyond Smart Cities

July 25, 2016 to July 27, 2016

The world is experiencing a period of extreme urbanization. In China alone, more than 250 million rural inhabitants will move to urban areas over the next 15 years. This will require building new infrastructure to accommodate nearly the equivalent of the current population of the United States in a matter of a few decades. Cities in the 21st century will account for nearly 90% of global population growth, 80% of wealth creation, and 60% of total energy consumption. It is a global imperative to develop systems that improve the livability of cities while dramatically reducing resource consumption. This course will focus on understanding the complexities of cities through the use of Big Data Urban Analytics and the design of New Urban Systems for high-density cities such as systems for mobility, energy, food, and living/working. The design of these systems must be resilient, scalable, and reconfigurable.

Today, academic research and industrial applications in the area of “Smart Cities” seek to optimize existing city infrastructure, networks, and urban behavior through the deployment and utilization of digital networks. Cities that employ optimization techniques have reported improvements in energy efficiency, water use, public safety, road congestion, and many other areas. However, optimization has its limits. For instance, the improvement of traffic flow in most cities can approach 10% based on current “Smart Cities” approaches such as sensing the road network, predicting the demand, and controlling traffic signaling. Research and investments in new urban systems are fundamentally critical because optimization will have little effect for rapidly urbanizing cities such as Bangalore, India, which experience around the clock congestion. This course moves beyond “Smart Cities” by focusing on disruptive innovations in technology, design, planning, policy, and strategies that can bring dramatic improvements in urban livability and sustainability.

This course aims to develop a holistic model for high-performance urban living based on the concept of “Compact Urban Cells” – a neighborhood area of approximately one square kilometer in diameter containing most of what citizens need for everyday life within a 20-minute walk. This course will introduce the following key elements for Compact Urban Cells:

  1. Resilient Urban Cells – compact, walkable neighborhood where places of living, work, culture, shopping, and play are within short reach and support a rich diversity of interactions and activities.
  2. New Mobility Systems – alternatives to the private fossil-fueled automobile are more convenient, affordable, pleasurable, and traffic congestion can be essentially eliminated: Electric-based and shared options.
  3. Resilient Energy Systems – microgrids, and locally-produced renewables create agile, adaptable, efficient energy networks.
  4. Living Space on Demand – hyper-efficient and transformable micro-apartments that are affordable, fun and productive for young professionals in the creative heart of the city.
  5. Shared Co-Working Facilities – co-working facilities, cafés, "fab labs" (fabrication laboratories), and other shared facilities support innovation and entrepreneurship.
  6. Urban Food Production – advanced urban agriculture systems integrated onto rooftops and façades of buildings efficiently deliver high-quality produce and help solve food security problems.
  7. Responsive Technologies – innovative systems enable powerful new applications that improve the life of each resident in areas of health, energy conservation, mobility, and communications.
  8. Trust Networks – privacy is assured for otherwise invasive systems that make use of highly personal data such as mobility patterns and resource consumption (food, water, energy, and individual health profiles).

The course will be divided into three learning methods 1) lectures by course faculty and guests from academia and industry, 2) participatory group design work in “charrette” sessions (a type of brainstorming), and 3) critique by faculty and invited experts. Using the MIT campus and the Kendall Square area as a potential site for deployment, course participants will work on a series of short in-class assignments that focus on solving practical urban problems. The goal of the workshop is for participants to engage in critical thinking about the technological, social, cultural, and economic challenges for achieving smart sustainable cities in order to return to their community, corporation, or institution to implement positive change.

Who Should Attend

Industry:
This program is designed for executives, business unit leaders and managers, financial investors and entrepreneurs, engineers/designers, and urban planners, from companies focused on the built environment, personal mobility and transit, energy, IT infrastructure, food, and Smart Cities development.

Government:
This program is also designed for government leaders charged with new urban economic development, design of new cities, and urban innovation districts or zones. Participants may include government leaders (e.g. mayors or vice-mayors), ministry and agency leaders, department directors, innovation managers, policymakers, city planners, and civil servants at the city, state, regional, or federal level. This course is open to government leaders in the U.S. and internationally.

Innovation: Beyond the Buzzword

July 25-27, 2016

We live in an age of exponential change in which rapid innovation is disrupting and unseating incumbent products and industries, creating new technological frontiers, and challenging nearly everything we think we know about business. For instance, think Uber and the end of the medallion taxi industry. Think Airbnb in twice as many countries as Hilton in less than 5 percent of the time. Think Tesla. Think Oculus. But beyond using the "buzzword," can you really define innovation?

In this course, which is centered on the concept of Design Thinking, your answer to that question will come from actually involving yourself in the activity of innovating.

The course will include lectures from faculty and guests, discussions of case studies in innovation models and methods, and learning expeditions on and beyond the MIT campus. But it will also go beyond these traditional classroom activities to include hands-on experiences with some cutting-edge innovations as well as group work and a class hackathon to engage in genuine innovating ? and through that, to gain an understanding beyond the buzzword. Participants will emerge as more critical thinkers, knowledgeable about what innovation is (and is not), how it happens, how to discern meaningful trends in design and technology, and how to identify opportunities and propose innovative products, services, and experiences. Active class participation, a willingness to engage with others in a creative process, and a recognition that you might have a lot to learn about innovation are all prerequisites for the course.

Who Should Attend: To facilitate the cross-pollination of ideas, approaches, and critical thought, professionals from all industries are welcome. People from across the functional business spectrum will find the course valuable, including strategy leaders, directors of innovation and technology, product managers, engineers, marketers, and R&D personnel. All participants must come with a willingness and enthusiasm to engage and be ready to share their particular passions and expertise.

Precision Medicine

July 25-29, 2016

Precision medicine promises to transform the pharmaceutical industry by integrating data from health care, wearables, and genomic and post-genomic tools to identify patients who will respond to particular therapies. In this course, we will examine the underlying scientific methods from genomics, systems biology, and data integration. We will also look at the technical, regulatory and ethical challenges.


WHO SHOULD ATTEND
This course will be of interest for research scientists from the pharmaceutical and biotech industries involved in clinical or preclinical research, as well as managers and scientists from the pharmaceutical and biotech industries responsible for strategic decision making. This course will also be of benefit to policy makers seeking to understand the risks and rewards of new technologies for biomedicine. Participants should have a scientific or medical background.

Product Platform and Product Family Design: From Strategy to Implementation

July 25-29, 2016

This course explores how product architecture, platforms and commonality can help a firm deploy and manage a family of products in a competitive manner. We will examine both strategic as well as implementation aspects of this challenge. A key strategy is to develop and manufacture a family of product variants derived from a common platform and/or modular architecture. Reuse of components, processes and design solutions leads to advantages in learning curves and economies of scale, which have to be carefully balanced against the desire for product customization and competitive pressures. Additionally, platform strategies can lead to innovation and generation of new revenue growth, by intelligently leveraging existing brands, modules, and sub-system technologies. We will present the latest theory as well as a number of case studies and industrial examples on this important topic. We will engage the course participants through interactive discussion and hands-on activities. Recent strategic issues such as embedding flexibility in product platforms as well as the effect of platforms on a firm's cost structure, organization, and market segmentation will also be presented.

WHO SHOULD ATTEND
This course is targeted towards executive decision makers, product managers, marketing managers, product line strategists, product architects, as well as platform and systems engineers in industrial and government contexts. Such individuals will have to strategically position their products and systems in a competitive marketplace and define modular and scalable product architectures, utilizing standardization, commonalization, customization and platform leveraging strategies to maximize cost savings while increasing the capability to offer a variety of customized systems and products. A basic background in mechanical and/or electrical engineering, as well as some business and accounting experience is beneficial but not required.

10th Anniversary Symposium
*Symposium registration is now open*

This year, 2016, will be the 10th anniversary of this course. A special symposium will be held on the afternoon of Friday, July 29 and Saturday, July 30 to look at the latest trends in industry and review successful industry case studies presented by past participants. The symposium will include keynote lectures, panel sessions, a digital poster session, and reception. Attendance for the first day of the symposium (Friday afternoon and evening) is included in the course fee. The fee for registrants wishing to also attend the second day of the symposium is $200; the option to add this will be available during checkout. Registration for the symposium alone is $449. Additional details can be found on the symposium information page.

Sustainability: Principles and Practice

July 25-29, 2016

This course will introduce participants to the goals, principles, and practical applications of sustainability. Many organizations, companies, and institutions are increasingly interested in conducting their activities while becoming more sensitive to environmental, social, and other concerns over a longer-term future. Sustainability has many definitions, and includes environmental, social, and economic dimensions. In this course, we will examine the major environmental issues and trends happening in modern society from a scientific and practical perspective, including energy and resource use, pollution, climate change, water, and population. Different definitions of sustainability will be introduced and discussed, and case studies will focus on examining and critiquing sustainability plans from organizations and institutions. The course will present practical skills for participants in the area of integrating sustainability into business practices, operations, policies, and research and development. New research will be presented by faculty working in the area of sustainability science and engineering at MIT.

WHO SHOULD ATTEND
This course is appropriate for professionals from a wide range of industries and sectors who are interested in organizational sustainability. Participants from local, state and federal government, especially those who are engaged in environmental and planning activities, would also benefit from the course.

Systems Engineering, Architecture, and Lifecycle Design: Principles, Models, Tools, and Applications

July 13-17, 2015

System and product complexities are increasing with time due to requirements for additional functionality, higher performance, competitive cost, schedule pressures, more flexibility or adaptability, and cognition-based friendlier human interface. Academics and practitioners alike have come to realize that complex engineering systems have a set of common principles, embedded in a theory, that goes beyond and cuts across the traditional fields of engineering. Novel products and systems development require the involvement of and communication between professionals with multiple disciplinary backgrounds and other stakeholders, notably the customer. This collaboration increases the likelihood of detecting product failures early on during its lifecycle, yielding significant cuts in time to market and heavy rework expenses.

The Systems Engineering discipline has been continuously growing in response to the increase in system and product complexity. System architecture is an early critical lifecycle activity that determines the system's concept and model of operation. Nurturing systems thinking and engineering skills, the engineering education this course provides grounds intuition and experience in theory and practice. We start with general SE and Systems Architecture principles. We then introduce SysML – the new SE standard from OMG. The approach underlying the system modeling is Object-Process Methodology (OPM), a comprehensive approach to systems architecting, conceptual modeling, and lifecycle support. An integrated engineering software environment, OPCAT, which combines intuitive graphics with an automatically-generated subset of English, implements OPM and supports the modeling of the system's requirements, top-level architecture, analysis and design models that are amenable to simulation and deployment. The resulting model can be translated to SysML and it constitutes a central underlying artifact of the system, which evolves and serves as a major reference to all the stakeholders throughout the entire lifecycle.

WHO SHOULD ATTEND
This program is intended for system architects, systems engineers, software engineers, system integrators, analysts and designers, executives, product developers, project leaders, project heads, systems biologists, banking and financial engineers and modelers, methods engineers, and database designers and administrators.

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